Mikail Gögenur

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Jeg er ansat som klinisk assistent hos Center for Surgical Science siden november 2019. Jeg har tidligere også haft et forskningsår i forskningsenheden. Jeg interesserer mig for hvordan den kirurgiske og onkologiske tilgang til patienterne kan forenes, så patienterne kan få den rigtige behandling på det rigtige tidspunkt. Her er det især immunforsvaret jeg interesserer mig for med fokus på at øge immunforsvarets aktivitet før kirurgisk og medicinsk onkologisk behandling. Derudover er jeg også interesseret i at identificere faktorer vigtige for at gennemføre medicinsk onkologisk behandling ved at benytte en big data og machine learning tilgang.

2015/September-2016/September: Skolar, Center for Surgical Science Kirurgisk afdeling, Sjællands Universitetshospital.

2017 Oktober-December: Lægevikar, Akutafdelingen, Slagelse Sygehus

2018/Maj- 2019/December: Lægevikar, Kirurgisk afdeling, Nykøbing Falster Sygehus.

2019/Maj-November: KBU-forløb, Lungemedicinsk afdeling, Hvidovre Hospital.

2019 November-2022 November: Klinisk assistent, Center for Surgical Science, Kirurgisk afdeling, Sjællands Universitetshospital.

2012-2014: Bsc. Med., Københavns Universitet

2014-2019: Cand. Med., Københavns Universitet

Min forskning er delt mellem et translationelt og et big data fokus. Translationelt er jeg interesseret i neoadjuverende tiltag der kan øge immunforsvarets aktivitet inden kurativ kirurgi hos patienter med kolorektal kræft. Derudover har jeg været en del af flere projekter med fokus på at identificere biomarkører der kan monitorere tumorbyrden hos patienter under kirurgisk og onkologisk behandling. Inden for big data er jeg interesseret i at identificere faktorer der er afgørende for at patienter har gavn af onkologisk medicinsk behandling.

 

  • Gögenur M, Balsevicius L, Bulut M, Colak N, Justesen TF, Fiehn AK, Jensen MB, Høst-Rasmussen K, Cappelen B, Gaggar S, Tajik A, Zahid JA, Bennedsen ALB, D’Ondes TDB, Raskov H, Sækmose SG, Hansen LB, Salanti A, Brix S, Gögenur I. ” Neoadjuvant intratumoral influenza vaccine treatment in patients with proficient mismatch repair colorectal cancer leads to increased tumor infiltration of CD8+ T cells and upregulation of PD-L1: a phase 1/2 clinical trial.” J Immunother Cancer. 2023 May;11(5):e006774. doi: 10.1136/jitc-2023-006774.
  • Justesen TF, Gögenur M, Clausen JSR, Mashkoor M, Rosen AW, Gögenur I. “The impact of time to surgery on oncological outcomes in stage I-III dMMR colon cancer – A nationwide cohort study.” Eur J Surg Oncol. 2023 Mar 24:S0748-7983(23)00418-3. doi: 10.1016/j.ejso.2023.03.223.
  • Kabel J, Henriksen TV, Demuth C, Frydendahl A, Rasmussen MH, Nors J, Birkbak NJ, Madsen AH, Løve US, Andersen PV, Kolbro T, Monti A, Thorlacius-Ussing O, Gögenur M, Kildsig J, Schlesinger NH, Bondeven P, Iversen LH, Gotschalck KA, Andersen CL. “Impact of Whole Genome Doubling on Detection of Circulating Tumor DNA in Colorectal Cancer.” Cancers (Basel). 2023 Feb 10;15(4):1136. doi: 10.3390/cancers15041136.
  • Gögenur M, Lindbjerg Andersen C, Gögenur I. “ ASO Author Reflections: Is ctDNA Detection an Accurate Measure of the Risk of Recurrence in Patients Undergoing Neoadjuvant Treatment?” Ann Surg Oncol. 2022 Aug 5. doi: 10.1245/s10434-022-12378-3.
  • Gögenur M, Hadi N, Qvortrup C, Andersen CL, Gögenur I. ”ctDNA for risk of recurrence assessment in patients treated with neoadjuvant treatment: A systematic review and meta-analysis”. Ann Surg Oncol. 2022 Aug 6. doi: 10.1245/s10434-022-12366-7
  • Bräuner KB, Rosen AW, Tsouchnika A, Walbech JS, Gögenur M, Lin VA, Clausen JSR, Gögenur I. “Developing prediction models for short-term mortality after surgery for colorectal cancer using a Danish national quality assurance database” Int J Colorectal Dis. 2022 Aug;37(8):1835-1843. doi: 10.1007/s00384-022-04207-6.
  • Lin V, Tsouchnika A, Allakhverdiiev E, Rosen AW, Gögenur M, Clausen JSR, Bräuner KB, Walbech JS, Rijnbeek P, Drakos I, Gögenur I. “Training prediction models for individual risk assessment of postoperative complications after surgery for colorectal cancer”. Tech Coloproctol. 2022 Aug;26(8):665-675. doi: 10.1007/s10151-022-02624-x.
  • Fiehn AMK, Reiss B, Gögenur M, Bzorek M, Gögenur I. “Development of a fully automated method to obtain reproducible lymphocyte counts in patients with colorectal cancer”. Appl Immunohistochem Mol Morphol. 2022:30(7):493-500. Doi: 10.1097/PAI.0000000000001041
  • Rosen AW, Gögenur M, Paulsen IW, Olsen J, Eiholm S, Kirkeby LT, Pedersen OB, Pallisgaard N, Gögenur I. “Perioperative changes in cell-free DNA for patients undergoing surgery for colon cancer”. BMC Gastroenterol. 2022;22(1):168. Doi: 10.1186/s12876-022-02217-w.
  • Gögenur M, Fransgård T, Krause TG, Thygesen LC, Gögenur I. ”Association of influenza vaccine and risk of recurrence in patients undergoing curative surgery for colorectal cancer”. Acta Oncol. 2021:60(11):1507-1512. Doi: 10.1080/0284186X.2021.1967444.
  • Vogelsang RP, Gögenur M, Dencker D, Bjørn Bennedsen AL, Levin Pedersen D, Gögenur I. “Routine CT evaluation of central vascular ligation in patients undergoing complete mesocolic excision for sigmoid colon cancer”. Colorectal Dis. 2021;23(8):2030-2040
  • Gögenur M, Fransgård T, Krause TG, Thygesen LC, Gögenur I. ”Association of postoperative influenza vaccine on overall mortality in patients undergoing curative surgery for solid tumors.” J. Cancer. 2021;148:1821-1827. Doi: 10.1002/ijc.33340
  • Henriksen TV, Reinert T, Christensen E, Sethi H, Birkenkamp-Demtröder K, Gögenur M, Gögenur I, Zimmermann BG, IMPROVE study group, Durskjøt L, Andersen CL. “The Effect of Surgical Trauma on Circulating Free DNA Levels in Cancer Patients – Implications for Studies of Circulating Tumor DNA.” Mol Oncol. 2020 May 29. Doi:10.1002/1878-0261.12729
  • Hangaard-Hansen C, Gögenur M, Madsen M, Gögenur I. ”The effect of time from diagnosis to surgery on oncological outcomes in patients undergoing surgery for colon cancer: a systematic review.”Eur J Surg Oncol, 2018 Oct;44(10): 1479-1485. Doi: 10.1016/j.ejso.2018.06.015.
  • Kirkegaard T, Gögenur M, Gögenur I. “Assessment of perioperative stress in colorectal cancer by use of in vitro cell models: a systematic review.” 2017 Nov 17;5:e4033. Doi: 10.7717/peerj.4033
  • Gögenur M, Hillig T, Gögenur I. ”CytoTrack analysis reveals low presence of circulating tumor cells in the perioperative period in patients with non-metastatic colorectal cancer.” Anticancer Res. 2017 Jun;37(6)_3099-3103
  • Gögenur M, Burchardt J, Gögenur I. “The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review.” Crit Care. 2017 Jan 24;21(1):14. Doi:10.1186/s13054-016-1578-9.
  • Gögenur M, Gögenur I. “Randomized Controlled Trial of the Intraportal Chemotherapy Combined With Adjuvant Chemotherapy (mFOLFOX6) for Stage II and III Colon Cancer.” Ann Surg. 2017 Dec;266(6):e105-e106. Doi:10.1097/SLA.000000000000001822
  • Gögenur M, Watt S.K., Gögenur I. “Immunrespons efter laparoskopisk versus åben kolorektal cancerkirurgi.” Laeger. 2015 jul 13; 177(29). Pii: V12140763

Forskning (keywords)

#Prædiktionsmodeller #Immunsystemet #Biomarkører #Komplikationer til kemoterapi 
LAST UPDATE: JUN 2023