I am a medical doctor and PhD-student interested in clinical oncology and cancer research. My fields of interest are especially related to the immune system in cancer development and progression. My goal is to become a Clinical Oncologist, specialized in the multimodal treatment of gastrointestinal cancers.
I am driven by my passion for knowledge and a life-long desire to become both a skilled and caring medical doctor. I seek constant improvement on both a professional and personal level.
I am striving for perfection in all aspects of life and aiming to “cure sometimes, treat often, comfort always” (Hippocrates).
- August 2021 – present | The Danish Ministry of Health
Medical Licensure (Selvstændigt virke)
- February 2017 – June 2020 | University of Copenhagen, Faculty of Health and Medical Sciences
Medical Doctor, MD.
- January 2014 – February 2017 | University of Copenhagen, Faculty of Health and Medical Sciences
Bachelor of Medicine
- August 2010 – June 2013 | Oerestad Gymnasium
High School Diploma. High level Mathematics and English.
My main research areas are the immune system’s involvement in cancer and how the immune system can be enhanced against cancer cells. I am involved in projects exploring biomarkers of response to immune enhancing treatments and experimental methods to switch cancer cells towards a phenotype that can be easier detected and eliminated by immune cells.
- 01.09.2021 – present:
Department of Surgery, Zealand University Hospital, Køge.
PhD-student. Clinical projects examining the immune profile and the tumor microenvironment (TME) in pancreatic cancer.
- 01.09.2021 – present:
Department of Oncology, Zealand University Hospital, Roskilde.
Preliminary Residency in Clinical Oncology.
- 18.12.2016 – present:
Aspiri A/S
Teaching in the following exam-prepation courses:
- Medical and Health Psychology for 1st year medical students.
- Heamatology, Oncology and Plastic Surgery for 4th year medical students.
Courses evalutaed to 4.8/5 and thus among best evaluated courses.
- 01.05.2020 – present:
Gyldendal Publishing, Munksgaard
Assistant Editor for the 4th edition of a Danish text book in surgery.
- 28.02.2021 – 31.08.2021:
Søndre Lægehus, Køge, Region of Zealand
Medical Intern.
- 01.09.2020 – 28.02.2021:
Emergency Department, Zealand University Hospital Køge
Medical Intern.
- 01.08.2017 – 01.08.2020:
University of Copenhagen, Biomedical Institute (BMI), Copenhagen
Assistant Lecturer in basic human biology for 1st year medical students.
Included macroscopic and microscopic anatomy demonstration.
- 01.08.2017 – 01.08.2020:
Department of Clinical Oncology, Herlev Hospital, Herlev
Research Assistant responsible for registering data om Danish patients with sarcoma in the Danish Sarcoma Database.
- 01.05.2017 – 01.06.2020:
Biotech Research and Innovation Centre (BRIC), Copenhagen
Student Assistant and Assistant Lecturer in basic pathology for 3rd year medical students. I held exam preparation lectures in basic cytology, neoplasia and tumorigenesis, inflammation and cardiovascular pathology.
- 01.02.2019 – 31.01.2020:
Department of Surgery, Zealand University Hospital, Køge
Pregraduate researcher at Center for Surgical Science.
- 01.01.2019 – 01.02.2019:
Department of Clinical Oncology, Rigshospitalet, Copenhagen
Student Assistant. I assisted in the maintenance and completion of case report forms for an international study on late and early radiotherapy among patients with prostate cancer (RADICALS trial), as well as other research related tasks at the department.
- 01.01.2018 – 01.01.2019:
Samfundslitteratur Publishing
Author of ”Kompendium i medicinsk psykologi og sundhedspsykologi”
The book is aimed for medical students.
- 26.06.2018 – 01.09.2018:
Department of Clinical Oncology, Rigshospitalet, Copenhagen
Locum Junior Doctor. I worked two months as a junior locum doctor at the Department of Clinical Oncology, Rigshospitalet, during a Summer break and obtained experience in independent patient rounding and acute patient care, as well as ordination of chemotherapy under supervision. I also attended staff educating sessions and presentations on: chemotherapy and antiemetics, emergency oncology, immunotherapy and common side effects, treatment of malignant pain, including palliation, and personalized medicine in oncology.
- 01.11.2017 – 01.05.2018:
Department of Surgery, Zealand University Hospital, Køge
Student Assistant. Assisted in the collection of patient data in a national randomized study, PIXIE.
- 01.08.2017 – 01.04.2018:
Department of Clinical Oncology, Rigshospitalet, Copenhagen
Student Assistant. Assisting in maintenance of RADICALS trial case report forms.
- 01.08.2015 – 31.1.2017:
Danish Cancer Society, Copenhagen
Research Assistant. I assisted in a randomised PhD-project on how music affects patients’ response to chemotherapy. My main tasks consisted of measuring patients’ blood pressure, processing blood samples and assisting in patient surveys and logbooks.
- 01.08.2013 – 01.02.2014:
Freelance Private Tutor
Private tutor. I have tutored middle school and high school students in German language, particularly in German grammar. My students went from D grades to A grades in both written and oral presentation.
- 01.08.2013 – 01.02.2014:
Zealand Private School
Substitute teacher. I primarily teached in science-classes such as biology and physics at secondary-school level but also substituted in subjects as Danish and English.
Orhan, Adile, Vogelsang, Rasmus Peuliche, Andersen, Malene Broholm, Madsen, Michael Tvilling, Hölmich, Emma Rosenkrantz, Raskov, Hans & Gögenur, Ismail. The prognostic value of tumour-infiltrating lymphocytes in pancreatic cancer: a systematic review and meta-analysis. European Journal of Cancer, 132, June 2020. https://doi.org/10.1016/j.ejca.2020.03.013
Orhan, Adile, Vogelsang, Rasmus Peuliche, Andersen, Malene Broholm, Madsen, Michael Tvilling, Hölmich, Emma Rosenkrantz, Raskov, Hans & Gögenur, Ismail. The prognostic value of tumour-infiltrating lymphocytes (TILs) in pancreatic cancer: A systematic review and meta-analysis: [Meeting Abstract]. Annals of Oncology. Dec 2019. 30, 8P. https://doi.org/10.1093/annonc/mdz447.006
Orhan, Adile, Gögenur, Ismail & Kissow, Hannelouise. The Intestinotrophic Effects of Glucagon-Like Peptide-2 in Relation to Intestinal Neoplasia. The Journal of Clinical Endocrinology and Metabolism, 2018. 103, 8, p. 2827-2837. https://doi.org/10.1210/jc.2018-00655
Orhan Adile, Khesrawi F, Tvilling Madsen M, Peuliche Vogelsang R, Dohrn N, Kanstrup Fiehn A-M, Gögenur I. Tumor-Infiltrating Lymphocytes as Biomarkers of Treatment Response and Long-Term Survival in Patients with Rectal Cancer: A Systematic Review and Meta-Analysis. Cancers. 2022; 14(3):636. https://doi.org/10.3390/cancers14030636
Hölmich, Emma Rosenkrantz, Hasselager, Rune Petring., Madsen, Michael Tvilling, Orhan, Adile & Gögenur, Ismail. Long-Term Outcomes after Use of Perioperative Glucocorticoids in Patients Undergoing Cancer Surgery: A Systematic Review and Meta-Analysis. Cancers, 2020. 12, 1, 22 p., 76. doi: 10.3390/cancers12010076
Raskov, Hans, Orhan, Adile, Salanti, Ali & Gögenur, Ismail. Premetastatic niches, exosomes and circulating tumor cells: Early mechanisms of tumor dissemination and the relation to surgery. International Journal of Cancer, 2020. 146, 12, p. 3244-3255.
https://doi.org/10.1002/ijc.32820
Raskov, Hans, Orhan, Adile, Pravsgaard Christensen, Jan. & Gögenur, Ismail. The Cytotoxic CD8+ T cell in Cancer and Cancer Immunotherapy. Bristish Journal of Cancer, 2020. https://doi.org/10.1038/s41416-020-01048-4
Ahmad Zahid, Jawad, Orhan, Adile, Ekeløf Busch, Sarah, Gögenur, Ismail. Myocardial Injury After Colorectal Cancer Surgery and Postoperative 90-Day Mortality and Morbidity: A Retrospective Cohort Study. Diseases of the Colon & Rectum. 2021;64 (12):1531-1541. 10.1097/DCR.0000000000002061
Vogelsang, Rasmus, Bojesen, Rasmus, Hölmich Rosenkrantz, Emma, Orhan, Adile, Buzquurz, Fatima et al. Prediction of 90-day Mortality after Surgery for Colorectal Cancer using Standardized Nationwide Quality Assurance Data. BJS Open. 2021:5(3) https://doi.org/10.1093/bjsopen/zrab023
Raskov, Hans, Orhan, Adile, Gaggar, Shruti. et al. Neutrophils and polymorphonuclear myeloid-derived suppressor cells: an emerging battleground in cancer therapy. Oncogenesis 11, 22 (2022). https://doi.org/10.1038/s41389-022-00398-3
Raskov, Hans, Orhan, Adile, Gaggar, Shruti Salanti, Ali & Gögenur Ismail. Natural Killer Cells in Cancer and Cancer Immunotherapy. Cancer Letters. 2021; 540: 233-242. https://doi.org/10.1016/j.canlet.2021.07.032
Raskov, Hans, Orhan, Adile, Gaggar, Shruti, Gögenur, Ismail. Influence of cancer-associated fibroblasts and tumour-associated macrophages on cancer and cancer immunotherapy. Frontiers in Oncology 2021:11. https://doi.org/10.3389/fonc.2021.668731
Justesen TF, Orhan Adile, Raskov H, Nolsoe C, Gögenur I. Electroporation and Immunotherapy—Unleashing the Abscopal Effect. Cancers. 2022; 14(12):2876. https://doi.org/10.3390/cancers14122876
Malene Broholm, Rasmus Bojesen, Mikail Gögenur, Andreas Weinberger Rosen, Sara Watt, Mustafa Bulut, Rasmus Vogelsang, Henning Quist Jensen, Adile Orhan […] Ismail Gögenur. Circulating Cell-Free DNA and Systemic Inflammatory Response after Self-Expandable Metal Stent for Malignant Bowel Obstruction. Archives of Microbiology and Immunology 6 (2022): 247-255.
Hans Raskov, Shruti Gaggar, Asma Tajik, Adile Orhan, Ismail Gögenur. Metabolic switch in cancer – Survival of the fittest. European Journal of Cancer, Volume 180, 2023, Pages 30-51. https://doi.org/10.1016/j.ejca.2022.11.025
Books and chapters:
Books
Adile Orhan. ”Kompendium i medicinsk psykologi og sundhedspsykolog”. Kompendie Forlaget, Samfundslitteratur. March 2018. 240 pages in total.
Chapters:
Orhan, A. (2022). The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. In: Interdisciplinary Cancer Research. Springer, Cham. https://doi.org/10.1007/16833_2022_65
Orhan, A. (2022). Cancer Immunodiagnosis in Upper Gastrointestinal Cancers. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham.
https://doi.org/10.1007/978-3-030-80962-1_147-1
Posters:
Adile Orhan, Rasmus P. Vogelsang, Malene B. Andersen, Michael T. Madsen, Emma R. Hölmich, Hans Raskov, Ismail Gögenur. The prognostic value of tumor-infiltrating lymphocytes (TILs) in pancreatic cancer: a systematic review and meta-analysis. ESMO Immuno-Oncology Congress; 2019 Dec 1-14; Geneva, Switzerland.
Emma R. Hölmich, Rune P. Hasselager, Michael T. Madsen, Adile Orhan, Ismail Gögenur. Long-term outcomes after use of perioperative glucocorticoids in patients undergoing cancer surgery: a systematic review and meta-analysis. Danish Surgical Society Annual Meeting; 2019 Oct 30 – Nov 1; Copenhagen, Denmark.
Charlotte Brinch, Estrid Høgdall, Pieter de Heer, Ninna Aggerholm Pedersen, Philip Rossen, Adile Orhan, Mathieu Molimard, Malene Møller Jørgensen, Anders Krarup-Hansen. A Danish prospective study including liquid biopsies, plasma concentration of tyrosine kinase inhibitors and Quality of Life in patients with Gastrointestinal Stromal Tumor. CTOS, Tokyo, November 2019.
- Danish Cancer Society’s scholar stipend, 120.000 DKK in 2019.
- Best oral presentation in upper GI research, Danish Surgical Society, November 2019.
- PhD-stipend from Region of Zealand of 500.000 DKK. August 2020.
- Grant of 167.000 DKK from Region of Zealand for my PhD thesis. February 2020.
- ESMO Immuno-Oncology Congress, Geneva, Schweiz, . December 2019. Poster Presentation.
- Danish Surgical Society, Copenhagen, November 2019. Mini-oral presentation.
- VuMedi, online presentation on TILs in pancreatic cancer, July 2020. VuMedi.com
Research keywords
LAST UPDATE: DEC 2022