My field of research focuses on electroporation in combination with calcium or bleomycin for gastrointestinal cancer. Electroporation is a method used to permeabilize cell membranes with high-voltage pulses. As a result, an increased flow of molecules across the cell membrane are observed, and allows passage of otherwise poorly or non-permeating substances such as calcium or chemotherapy, e.g. bleomycin. Studies have shown that electrochemotherapy (with bleomycin) and calcium electroporation effectively eliminate cancer cells, and furthermore, may induce a favorable immunologic response.
My field of research also includes investigation of self-expanding metal stent (SEMS) for bowel obstruction. Up to 30 % of all patients with colorectal carcinoma present with acute malignant obstruction. SEMS was introduced as an alternative to emergency surgery. The expected benefit of SEMS as a bridge to surgery was the opportunity to optimize the patient’s clinical condition before surgery, with less morbidity, mortality and need for a stoma. However, studies have failed to show beneficial effects of SEMS compared with emergency surgery, regarding morbidity and mortality. Furthermore, studies indicate a worse prognosis in relation to stent as bridge to surgery.
SEMS may have a major impact on histopathological and immunological changes in the tumor tissue. We aim to identify changes in tumor microenvironment and systemic immune response following stent placement.
2017 – Ph.d. student, Center for Surgical Science, Zealand Universitetshospital
2017 Resident, Department of Surgery, Nykøbing Falster Hospital
2015 Resident, Department of Surgery, North Region of Denmark
2014-2015 Scholar student, CPO, Department of Surgery, Herlev Hospital
2014-2015 Prægraduat forskningsår, CPO, Gastroenheden, Herlev Hospital
- M Broholm, M Kobborg, E Frostberg et al. Delay of surgery after stent placement for resec-table maglinant colorectal obstruction is associated with higher risk of recurrence. International Journal of Colorectal Disease. 2016
- M Broholm, I Onsberg, J Rosenberg. Limited evidence for robot-assisted surgery: a system-atic review and meta-analysis of randomized controlled trials. SLEPT. 2016
- M Broholm, HC Pommergaard, I Gögenür. Possible benefits of robot-assisted rectal cancer surgery regarding urological and sexual dysfunction: a systematic review and meta-analysis. Colorectal Disease. 2015.
- M Broholm, J Rosenberg. Surgical residents are excluded from robot-assisted surgery. SLEPT 2015.
- M Broholm, H Møller, I Gögenür. Seksuel dysfunktion er hyppig hos patienter med analfistler og analfissurer. Ugeskrift for Læger. 2015.
- M Broholm, P Jess. Ringe evidens for anvendelse af selvekspanderende metalstent ved malign kolorektal obstruktion. Ugeskrift for Læger 2014;176.
- M Kobborg, M Broholm, E Frostberg, M Jeppesen, I Gögenür. Short-term results of self-expanding metal stents for acute malignant large bowel obstruction. Colorectal Disease. 2017
- A Schmiegelow, M Broholm, I Gögenür. Evaluation of sexual and urinary function after implementation of robot assisted surgery for rectal cancer: a single center study. SLEPT. 2015
- MH Jeppesen, AQ Fenger, M Broholm. Korrekt budgettering af forskningsmidler. Ugeskrift for Læger. 2014;176.
- Laursen J, M Broholm, Rosenberg J. Health professionals perceive teamwork with relatives as an obstacle in their daily work – a focus group interview. Scandinavian Journal of Car-ing Sciences.
LAST UPDATE: SEP 2019