{"id":14342,"date":"2025-03-05T12:32:18","date_gmt":"2025-03-05T10:32:18","guid":{"rendered":"https:\/\/centerforsurgicalscience.dk\/?page_id=14342"},"modified":"2025-03-28T13:03:31","modified_gmt":"2025-03-28T11:03:31","slug":"colorectal-cancer-projects","status":"publish","type":"page","link":"https:\/\/centerforsurgicalscience.dk\/da\/colorectal-cancer-projects\/","title":{"rendered":"Colorectal cancer projects"},"content":{"rendered":"
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COLORECTAL CANCER
PROJECTS<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tThe SparCol study: Organ SPARring surgery vs. standard resection for early stage COLon cancer in elderly frail patients.<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>: <\/span>Ismail G\u00f6genur<\/a> & Ilze Ose<\/a><\/span><\/p>

Aim<\/strong>: <\/span>The primary aim of this randomized clinical trial (RCT) is to investigate if we can improve the quality of recovery and reduce the risk of complications in elderly frail patients with small colon cancers with an organ preserving approach (CELS) compared with standard surgery<\/span><\/p>

Status<\/strong>: <\/span>Recruiting since april 2023. 6 out of 48 patients are included.<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tMEFO trial: Preoperative endoscopic treatment with fosfomycin and metronidazole in patients with right-sided colon cancer and colon adenoma: a clinical proof-of-concept intervention study<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator: <\/span><\/strong>Astrid Louise Bj\u00f8rn Bennedsen<\/span><\/a><\/p>

Aim:<\/strong> <\/span>The aim of this study is to investigate the effect of local antibiotic treatment with fosfomycin and metronidazole on tumor characteristics and the colonic biofilm in patients with right-sided colon cancer or right-sided colon adenomas.<\/span><\/p>

Status: <\/span><\/strong>Data analysis ongoing and manuscript in progress.<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tMyeloid-derived suppressor cells in the peripheral blood and the spatial distribution in tumour tissue of patients with colorectal cancer<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>: Previous <\/span>Hans Raskov – now our laboratory team<\/span><\/p>

Aim: <\/span><\/strong>Tumor-secreted factors cause immunosuppression by driving alternatively activated, protumorigenic immune cells (MDSCs) to move from the bone marrow to the circulation, promoting disese progression and negatively affecting treatment responses. Using a novel flowcytometry analysis, we have identified and quantified three classes of MDSCs in CRC, and confirmed their immuno-suppressive capacity. Moving forward, we will investigate the MDSC spatial distribution in the TME to better understand tumor cell immune evasion and the impact on treatment outcomes.<\/span><\/p>

Status:<\/strong> <\/span>We are finalizing blood collection and performing the flow cytometry on 25 CRC patients. Q1-2 data analysis will be performed by our collaborators at DTU and Q2-3 GeoMx analyses on 25 tumours will take place at the research lab at CSS.<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tFLU-IMMUNE trial: Combining intratumoral flu vaccine treatment with pembrolizumab in patients with colorectal cancer: A phase 2 clinical trial<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>: <\/span>Ismail G\u00f6genur<\/a>, Adile Orhan<\/a> & Mikail G\u00f6genur<\/a><\/span><\/p>

Aim<\/strong>: <\/span>Investigate if the combination of intratumoral flu vaccine and the immunotherapy pembrolizumab results in cancer cell death in patients with pMMR colorectal<\/span> cancer<\/span><\/p>

Status<\/strong>: <\/span>Actively including, 4 patients included<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tDifferential impact of 30-day postoperative infections on one-year mortality in 859,766 individuals undergoing gastrointestinal surgery<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>: <\/span>Doruk Orgun<\/span><\/a><\/p>

Aim<\/strong>: <\/span>The aim of this study is to assess and understand the changes in treatment decisions by the colorectal cancer multidisciplinary team when using or not using machine-learning models as decision support, specifically in use of neoadjuvant treatment, prehabilitation, and choosing no surgery at all<\/span><\/p>

Status<\/strong>:<\/span> Awaiting status<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t The impact of electroporation with Bleomycine and with Calcium have an impact on tumor immunology in advanced and early rectosigmoid cancer<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>:<\/span> Loan Tuyet Ngo-Stuyt, Mikail G\u00f6genur<\/a> & Rasmus Vogelsang<\/span><\/p>

Aim<\/strong>:<\/span> To test treatment with electroporation preceeded by iv Bleomycine or Calcium intratumorally have a positive impact on tumor biology in advanced rectal and early rectosigmoid cancer<\/span><\/p>

Status<\/strong>: <\/span>Manuscript in progress<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEksploration protocol: In vitro studies for improvement and development of methods to investigate gastrointestinal diseases<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

P<\/span>I\/Investigator: <\/span><\/strong>Ismail G\u00f6genur<\/a>, Katrine H\u00f8st<\/a><\/span><\/p>

Aim: <\/span><\/strong>The aim is to characterise disease development in correlation to cellular, molecular and bacterial factors. As part of this aim, we have established biobank material from organoids, blood, and tissue from patients with and without cancer<\/span>.<\/span><\/p>

Status: <\/span><\/strong><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tThe IPOS trial: Effect of low-dose interferon-alfa2a on peri operative immune suppression.<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>: <\/span>Helin Yikilmaz Pardes<\/span><\/p>

Aim<\/strong>: <\/span>The study is a randomized double-blinded placebo-controlled phase 2 study. We aim to determine the efficacy of preoperative treatment with interferon-alfa2a in patients with pMMR colon cancer on perioperative immune suppression and tumorinfiltrating lymphocytes in the primary tumor.<\/span><\/p>

Status<\/strong>: <\/span>We have included 30 out of 68 patients.<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tUse of Combined endoscopic laparoscopic resection in advanced adenomas and early colon cancers<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>:<\/span> Mustafa Bulut<\/span><\/p>

Aim<\/strong>:<\/span> To describe in a consecutive group of more than 200 patients the results of minimally invasive techniques in advanced colon adenomas and early colorectal lesions<\/span><\/p>

Status:<\/span><\/strong> Manuscript in progress<\/span><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tSingle cell representation of the tumor microenvironment in patients with dMMR colon cancer undergoing neoadjuvant immune therapy<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI:<\/strong> Lukas Balsevicius & Ismail G\u00f6genur<\/p>

Aim: <\/strong>To investigate if there are any single cell tumor stromal or immune cell markers that may have a value for predicting complete pathological response in patients receiving neoadjuvant pembrolizumab.<\/p>

Status: <\/strong>Clinical study finalized, translational analyses finalized in Q3, 2025<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tThe effect of melatonin in patients with Low Anterior Resection Syndrome \u2013 a randomized, placebo-controlled, cross-over trial<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator<\/strong>: Jawad Ahmad Zahid & Ismail G\u00f6genur<\/p>

Aim:<\/strong> To investigate if melatonin has an alleviating effect on Low Anterior Resection Syndromesymptoms. Secondarily, to examine treatment effect on bowel function, various patient reported outcomes, and inflammation.<\/p>

\u00a0<\/p>

Status:<\/strong> Patient inclusion complete, analyses and manuscript pending<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tPredictive Biomarker Analysis for Tailored Neoadjuvant Therapy in Locally Advanced Rectal Cancer \u2013 Insights from the NEOLAR Trial<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator: <\/strong>Mia Kristina Stubseid S\u00f8rensen<\/p>


Aim: <\/strong>\u00a0To investigate the predictive value of selected biomarkers in diagnostic biopsies from rectal cancer patients in the NEOLAR trial using digital image analysis and spatial profiling techniques, with the goal of exploring their potential for optimizing patient selection for neoadjuvant therapy.<\/p>

Status:<\/strong> Tissue samples have been retrieved, and the selection of tissue areas for biomarker analysis is in progress. Immunohistochemistry, digital image analysis, and spatial profiling are in the planning phase.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tPredicting patient trajectories in oncological surgery<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

PI\/Investigator: <\/strong>Puck Quarles van Ufford<\/a>, Ole Lund (DTU), Lars R\u00f8nn Olsen (KU), Ismail G\u00f6genur<\/a>, Martin H\u00f8yer Rose<\/a><\/p>

Aim: <\/strong>My PhD \u00a0consists of 3 different projects:<\/p>